diff --git a/lib/modules/manager/pip-compile/__fixtures__/requirementsWithUV.txt b/lib/modules/manager/pip-compile/__fixtures__/requirementsWithUV.txt
new file mode 100644
index 000000000000000..81270c095e36256
--- /dev/null
+++ b/lib/modules/manager/pip-compile/__fixtures__/requirementsWithUV.txt
@@ -0,0 +1,10 @@
+# This file was autogenerated by uv via the following command:
+#    uv pip compile --generate-hashes --output-file=requirements.txt --universal requirements.in
+attrs==21.2.0 \
+    --hash=sha256:149e90d6d8ac20db7a955ad60cf0e6881a3f20d37096140088356da6c716b0b1 \
+    --hash=sha256:ef6aaac3ca6cd92904cdd0d83f629a15f18053ec84e6432106f7a4d04ae4f5fb
+    # via -r requirements.in
+setuptools==59.2.0 \
+    --hash=sha256:157d21de9d055ab9e8ea3186d91e7f4f865e11f42deafa952d90842671fc2576 \
+    --hash=sha256:4adde3d1e1c89bde1c643c64d89cdd94cbfd8c75252ee459d4500bccb9c7d05d
+    # via -r requirements.in
diff --git a/lib/modules/manager/pip-compile/artifacts.spec.ts b/lib/modules/manager/pip-compile/artifacts.spec.ts
index 6818e35d0550d69..97e5c1114cdb12d 100644
--- a/lib/modules/manager/pip-compile/artifacts.spec.ts
+++ b/lib/modules/manager/pip-compile/artifacts.spec.ts
@@ -488,6 +488,19 @@ describe('modules/manager/pip-compile/artifacts', () => {
       );
     });
 
+    it('returns extracted arguments for uv ', () => {
+      expect(
+        constructPipCompileCmd(
+          extractHeaderCommand(
+            Fixtures.get('requirementsWithUv.txt'),
+            'subdir/requirements.txt',
+          ),
+        ),
+      ).toBe(
+        'uv pip compile --generate-hashes --output-file=requirements.txt --universal requirements.in',
+      );
+    });
+
     it('returns --no-emit-index-url when credentials are found in PIP_INDEX_URL', () => {
       process.env.PIP_INDEX_URL = 'https://user:pass@example.com/pypi/simple';
       expect(
diff --git a/lib/modules/manager/pip-compile/artifacts.ts b/lib/modules/manager/pip-compile/artifacts.ts
index 5d8bafb46d4220c..3608808a6a869b4 100644
--- a/lib/modules/manager/pip-compile/artifacts.ts
+++ b/lib/modules/manager/pip-compile/artifacts.ts
@@ -57,7 +57,7 @@ export function constructPipCompileCmd(
   compileArgs: PipCompileArgs,
   upgradePackages: Upgrade[] = [],
 ): string {
-  if (compileArgs.isCustomCommand) {
+  if (compileArgs.commandType === 'custom') {
     throw new Error(
       'Detected custom command, header modified or set by CUSTOM_COMPILE_COMMAND',
     );
@@ -68,6 +68,7 @@ export function constructPipCompileCmd(
   }
   // safeguard against index url leak if not explicitly set by an option
   if (
+    compileArgs.commandType === 'pip-compile' &&
     !compileArgs.noEmitIndexUrl &&
     !compileArgs.emitIndexUrl &&
     haveCredentialsInPipEnvironmentVariables()
@@ -115,6 +116,7 @@ export async function updateArtifacts({
       }
       const compileArgs = extractHeaderCommand(existingOutput, outputFileName);
       const pythonVersion = extractPythonVersion(
+        compileArgs.commandType,
         existingOutput,
         outputFileName,
       );
diff --git a/lib/modules/manager/pip-compile/common.spec.ts b/lib/modules/manager/pip-compile/common.spec.ts
index a465e9a9bccf5f0..ca069568d149e68 100644
--- a/lib/modules/manager/pip-compile/common.spec.ts
+++ b/lib/modules/manager/pip-compile/common.spec.ts
@@ -2,7 +2,7 @@ import { mockDeep } from 'jest-mock-extended';
 import { hostRules } from '../../../../test/util';
 import { logger } from '../../../logger';
 import {
-  allowedPipOptions,
+  allowedOptions,
   extractHeaderCommand,
   extractPythonVersion,
   getRegistryCredVarsFromPackageFiles,
@@ -137,8 +137,8 @@ describe('modules/manager/pip-compile/common', () => {
       ).toEqual(exampleSourceFiles);
     });
 
-    it.each(allowedPipOptions)(
-      'returned sourceFiles must not contain options',
+    it.each(allowedOptions['pip-compile'])(
+      'returned sourceFiles must not contain options (pip-compile)',
       (argument: string) => {
         const sourceFiles = extractHeaderCommand(
           getCommandInHeader(`pip-compile ${argument}=reqs.txt reqs.in`),
@@ -149,13 +149,25 @@ describe('modules/manager/pip-compile/common', () => {
       },
     );
 
+    it.each(allowedOptions['uv'])(
+      'returned sourceFiles must not contain options (uv)',
+      (argument: string) => {
+        const sourceFiles = extractHeaderCommand(
+          getCommandInHeader(`uv pip compile ${argument}=reqs.txt reqs.in`),
+          'reqs.txt',
+        ).sourceFiles;
+        expect(sourceFiles).not.toContainEqual(argument);
+        expect(sourceFiles).toEqual(['reqs.in']);
+      },
+    );
+
     it('detects custom command', () => {
       expect(
         extractHeaderCommand(
           getCommandInHeader(`./pip-compile-wrapper reqs.in`),
           'reqs.txt',
         ),
-      ).toHaveProperty('isCustomCommand', true);
+      ).toHaveProperty('commandType', 'custom');
     });
 
     it.each([
diff --git a/lib/modules/manager/pip-compile/common.ts b/lib/modules/manager/pip-compile/common.ts
index 5a2126198900be7..dc40ab89fc3922e 100644
--- a/lib/modules/manager/pip-compile/common.ts
+++ b/lib/modules/manager/pip-compile/common.ts
@@ -9,7 +9,7 @@ import { ensureLocalPath } from '../../../util/fs/util';
 import * as hostRules from '../../../util/host-rules';
 import { regEx } from '../../../util/regex';
 import type { PackageFileContent, UpdateArtifactsConfig } from '../types';
-import type { PipCompileArgs, SupportedManagers } from './types';
+import type { CommandType, PipCompileArgs, SupportedManagers } from './types';
 
 export function getPythonVersionConstraint(
   config: UpdateArtifactsConfig,
@@ -83,24 +83,45 @@ export const constraintLineRegex = regEx(
 export const disallowedPipOptions = [
   '--no-header', // header is required by this manager
 ];
-export const optionsWithArguments = [
+const commonOptionsWithArguments = [
   '--output-file',
   '--extra',
   '--extra-index-url',
+];
+const pipOptionsWithArguments = [
   '--resolver',
   '--constraint',
+  ...commonOptionsWithArguments,
+];
+const uvOptionsWithArguments = ['--constraints', ...commonOptionsWithArguments];
+export const optionsWithArguments = [
+  ...pipOptionsWithArguments,
+  ...uvOptionsWithArguments,
 ];
-export const allowedPipOptions = [
+const allowedCommonOptions = [
   '-v',
-  '--all-extras',
-  '--allow-unsafe',
   '--generate-hashes',
-  '--no-emit-index-url',
   '--emit-index-url',
-  '--strip-extras',
   '--index-url',
-  ...optionsWithArguments,
 ];
+export const allowedOptions: Record<CommandType, string[]> = {
+  'pip-compile': [
+    '--all-extras',
+    '--allow-unsafe',
+    '--generate-hashes',
+    '--no-emit-index-url',
+    '--strip-extras',
+    ...allowedCommonOptions,
+    ...pipOptionsWithArguments,
+  ],
+  uv: [
+    '--no-strip-extras',
+    '--universal',
+    ...allowedCommonOptions,
+    ...uvOptionsWithArguments,
+  ],
+  custom: [],
+};
 
 // TODO(not7cd): test on all correct headers, even with CUSTOM_COMPILE_COMMAND
 export function extractHeaderCommand(
@@ -118,23 +139,33 @@ export function extractHeaderCommand(
   );
   const command = compileCommand.groups.command;
   const argv = [command];
-  const isCustomCommand = command !== 'pip-compile';
+  let commandType: CommandType;
+  if (command === 'pip-compile') {
+    commandType = 'pip-compile';
+  } else if (command === 'uv') {
+    commandType = 'uv';
+  } else {
+    commandType = 'custom';
+  }
   if (compileCommand.groups.arguments) {
     argv.push(...split(compileCommand.groups.arguments));
   }
   logger.debug(
-    { fileName, argv, isCustomCommand },
+    { fileName, argv, commandType },
     `pip-compile: extracted command from header`,
   );
 
   const result: PipCompileArgs = {
     argv,
     command,
-    isCustomCommand,
+    commandType,
     outputFile: '',
     sourceFiles: [],
   };
   for (const arg of argv.slice(1)) {
+    if (commandType === 'uv' && ['pip', 'compile'].includes(arg)) {
+      continue;
+    }
     // TODO(not7cd): check for "--option -- argument" case
     if (!arg.startsWith('-')) {
       result.sourceFiles.push(arg);
@@ -142,7 +173,7 @@ export function extractHeaderCommand(
     }
     throwForDisallowedOption(arg);
     throwForNoEqualSignInOptionWithArgument(arg);
-    throwForUnknownOption(arg);
+    throwForUnknownOption(commandType, arg);
 
     if (arg.includes('=')) {
       const [option, value] = arg.split('=');
@@ -153,7 +184,7 @@ export function extractHeaderCommand(
         result.extraIndexUrl = result.extraIndexUrl ?? [];
         result.extraIndexUrl.push(value);
         // TODO: add to secrets? next PR
-      } else if (option === '--constraint') {
+      } else if (['--constraint', '--constraints'].includes(option)) {
         result.constraintsFiles = result.constraintsFiles ?? [];
         result.constraintsFiles.push(value);
       } else if (option === '--output-file') {
@@ -210,9 +241,13 @@ const pythonVersionRegex = regEx(
 );
 
 export function extractPythonVersion(
+  commandType: CommandType,
   content: string,
   fileName: string,
 ): string | undefined {
+  if (commandType === 'uv') {
+    return
+  }
   const match = pythonVersionRegex.exec(content);
   if (match?.groups === undefined) {
     logger.warn(
@@ -244,14 +279,14 @@ function throwForNoEqualSignInOptionWithArgument(arg: string): void {
     );
   }
 }
-function throwForUnknownOption(arg: string): void {
+function throwForUnknownOption(commandType: CommandType, arg: string): void {
   if (arg.includes('=')) {
     const [option] = arg.split('=');
-    if (allowedPipOptions.includes(option)) {
+    if (allowedOptions[commandType].includes(option)) {
       return;
     }
   }
-  if (allowedPipOptions.includes(arg)) {
+  if (allowedOptions[commandType].includes(arg)) {
     return;
   }
   throw new Error(`Option ${arg} not supported (yet)`);
diff --git a/lib/modules/manager/pip-compile/readme.md b/lib/modules/manager/pip-compile/readme.md
index cb846fb0a78d42a..1432bb4f4c470a1 100644
--- a/lib/modules/manager/pip-compile/readme.md
+++ b/lib/modules/manager/pip-compile/readme.md
@@ -1,6 +1,8 @@
 Due to limited functionality, the `pip-compile` manager should be considered in an "alpha" stage, which means it's not ready for production use for the majority of end users.
 We welcome feedback and bug reports!
 
+The `uv pip compile` command is also supported through this manager in the same fashion as `pip-compile`.
+
 The current implementation has some limitations.
 Read the full document before you start using the `pip-compile` manager.
 
diff --git a/lib/modules/manager/pip-compile/types.ts b/lib/modules/manager/pip-compile/types.ts
index c496e01c886a7db..ad0b9dcaf6c29b0 100644
--- a/lib/modules/manager/pip-compile/types.ts
+++ b/lib/modules/manager/pip-compile/types.ts
@@ -5,10 +5,12 @@ export type SupportedManagers =
   | 'setup-cfg'
   | 'pep621';
 
+export type CommandType = 'pip-compile' | 'uv' | 'custom';
+
 export interface PipCompileArgs {
   argv: string[]; // all arguments as a list
   command: string;
-  isCustomCommand: boolean;
+  commandType: CommandType;
   constraintsFiles?: string[];
   extra?: string[];
   allExtras?: boolean;